The Dallas hospital at the heart of three US ebola cases has taken out a full-page newspaper advert to apologise for its failings.
Barclay Berdan, the CEO of Texas Health Presbyterian, said that "mistakes were made in handling a very difficult challenge" after two nurses contracted the deadly virus from Thomas Eric Duncan.
The 42-year-old, from Liberia, was the first person to be diagnosed with ebola outside West Africa.
But in an open letter, published in the Dallas Morning News, the hospital admitted it "did not correctly diagnose his symptoms as those of ebola – and for this, we are deeply sorry".
Mr Berdan added: "In short, despite our best intentions and skilled medical teams, we did not live up to the high standards that are the heart of our hospital's history, mission and commitment."
The executive used the advert to reject accusations that his hospital fell short of CDC guidelines on treating ebola, amid criticism over how two of its nurses, Nina Pham and Amber Vinson, contracted the disease from Mr Duncan.
"Many of the theories and allegations being presented in the media do not align with facts stated in the medical record and the accounts of caregivers present on the scene," Mr Berdan wrote.
Texas Presbyterian, which said it is "praying these US-based cases of ebola will also be the last", has seen its patient numbers plummet since becoming one of the first hospitals in the States to deal with ebola.
Some people in desperate need of emergency treatment have asked paramedics to take them to other hospitals further away, while hundreds of others have cancelled their appointments.
"It feels like a ghost town. No one is even walking around the hospital," one worker told local television.
The plummeting confidence among prospective patients in Dallas came as President Obama urged Americans not to "give in to hysteria or fear" over the ebola virus.
Elsewhere in Texas, a cruise ship carrying a quarantined Presbyterian worker has docked in Galveston after it was refused entry into some foreign harbours.
Described as a "floating petri dish" by one traveller, the Carnival Magic ship arrived on Sunday afternoon and a lab technician on-board was allowed to leave after showing no ebola symptoms.
There were fears the medic may have come into contact with bodily fluids from Mr Duncan that had been submitted for tests.
The UK's International Development Secretary, Justine Greening MP, told Sky News: "The cases in the US show we need to be taking action to make sure we have the necessary precautions in place."
Meanwhile, a World Health Summit is set to open in Berlin, with Germany's foreign minister, Frank-Walter Steinmeier, due to make a speech on the crisis.
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