The US is sending up to 3,000 troops to West Africa to co-ordinate the response to the ebola outbreak.
The virus has claimed more than 2,200 lives this year - mostly in Liberia, Sierra Leone and Guinea.
On a visit to the federal Centers for Disease Control and Prevention in Atlanta, Georgia, President Barack Obama is set to outline measures to support overwhelmed health services in areas affected by the epidemic, amid fears it could continue to spread.
Ahead of the announcement, unnamed administration officials revealed they would build 17 health care facilities in the region, each with 100 beds.
The US has already spent $100m (£62m) in response to the outbreak The US will attempt to train 500 medical staff a week, provide health kits to hundreds of thousands of homes and educate communities on how to tackle the problem.
The cost of the aid will be $500m (£308m), the officials said.
It is expected to take two weeks to get US personnel on the ground.
Ebola, which has also reached Nigeria and Senegal, is spread through direct contact with the bodily fluids of sick patients. There is no vaccine or approved treatment.
US ebola victims Dr Kent Brantly and Nancy Writebol Four Americans have been or are being treated for ebola in the US after evacuation from Africa.
The country's intervention follows demands for a stepped-up international response.
The US ambassador to the United Nations, Samantha Power, has called for an emergency meeting of the Security Council, warning the virus could "set the countries of West Africa back a generation".
US efforts will include medics and corpsmen, engineers to help build treatment facilities and logistics specialists to assist in patient transportation.
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