Three cell biologists at US universities have won the 2013 Nobel Prize in medicine for discoveries on how hormones, enzymes and other substances are transported within cells.
The three recipients are Americans James Rothman and Randy Schekman and German-born researcher Thomas Suedhof.
The committee said their research on the transport system of our cells shed light on how all key substances are "delivered to the right place at the right time" inside cells.
The prize in medicine kicks off this year's Nobel announcements "Imagine hundreds of thousands of people who are travelling around hundreds of miles of streets; how are they going to find the right way? Where will the bus stop and open its doors so that people can get out?" Nobel committee secretary Goran Hansson said.
"There are similar problems in the cell."
Disturbances to the system can contribute to diabetes and neurological and immunological disorders, the committee said.
"My first reaction was, 'Oh, my God!'" Mr Schekman, 64, said in a statement released by his university, Berkeley.
"That was also my second reaction."
Mr Rothman, 62, is a professor at Yale University while Mr Suedhof, 57, joined Stanford University in 2008.
The Nobel committee said Mr Schekman discovered a set of genes that were required for a transport system of our cells known as "vesicle transport".
Mr Rothman revealed how proteins dock with their target membranes like two sides of a zipper, while Mr Suedhof found out how vesicles release their cargo with precision.
"These discoveries have had a major impact on our understanding of how cargo is delivered with timing and precision within and outside the cell," the committee said in their announcement.
The medicine prize kicked off this year's Nobel awards.
The awards in physics, chemistry, literature, peace and economics will be announced by other prize juries this week and next.
Each prize is worth 8m Swedish kronor (£750,000 or $1.2m ).
Established by Swedish industrialist Alfred Nobel, the prizes have been handed out by award committees in Stockholm and Oslo since 1901.
The winners receive their awards on December 10, the anniversary of Mr Nobel's death in 1896.
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